Emmanuel Pauthe, responsable de l’axe Biomatériaux pour la Santé au sein d’ERRMECe, présentera un séminaire intitulé « Proactive biomaterials: biomimetic interfacial properties and advanced delivery systems » le 23/11/2016 à 13h à l’université Catholique de Louvain.
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Résumé du Séminaire
Directing cell behavior is a key contemporary challenge in biomaterials science. Engineering advanced materials, able to proactively and efficiently “dialogue” with surrounding tissues, is at the heart of the work of the Biomaterials for Health group, led by Emmanuel Pauthe of the University of Cergy-Pontoise, France. Our activities are principally focused on the dynamics of extracellular matrix and biopolymer component assembly – at the molecular and supramolecular scales – in solution, at interfaces,and in biomaterials applications. During this seminar, two recent projects will be highlighted. The first involves polyelectrolyte-based films, formed via layer-by-layer assembly. In particular, strategies are presented involving i) nanotemplating, to spatially and temporally release bioactive molecules (e.g. BMP2), and ii) intrafilm fibronectin placement, for films with exceptionally high matrix protein content. The second project involves the engineering of a hydrogel scaffold glucose delivery system for enhancing mesenchymal stem cells survival. Such a system addresses a significant tissue engineering challenge: the massive death of transplanted cells that typically occurs following engraftment using currently available scaffolds. By supplying glucose in situ as a metabolic fuel for Mesenchymal Stem Cells (MSCs) in severe hypoxia, this new scaffold is shown to significantly enhance MSC survival. These strategies represent appealing bioactive systems able to enhance cell adhesion, spreading, proliferation and differentiation, and offer great potential toward a variety of cell contacting applications.